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HIV/AIDS Clinical Care
Stay informed on the changing landscape of HIV care with perspectives on the latest research, antiretroviral alerts, and succinct case discussions from our expert clinicians.
Featured Article
NEWS IN CONTEXT
New CDC Interim Guidance on HIV and H1N1Free
- November 2, 2009
- Carlos del Rio, MD
HIV-infected individuals are a high-priority group for prevention and treatment of 2009 H1N1 influenza.
- Reviewing:
- Centers for Disease Control and Prevention (CDC). 2009 Oct 21
Recent HIV/AIDS Clinical Care Articles
SUMMARY AND COMMENT
Darunavir + Raltegravir + Etravirine = High Rate of Treatment Success
- November 2, 2009
- Paul E. Sax, MD
Ninety percent of highly treatment-experienced patients who received this combination achieved virologic suppression at week 24; results were sustained at week 48.
- Reviewing:
- Yazdanpanah Y et al. Clin Infect Dis 2009 Nov 1; 49:1441
SUMMARY AND COMMENT
Dose Reduction Curbs Efavirenz Toxicity
- November 2, 2009
- Abigail Zuger, MD
Reducing the daily dose of efavirenz to 400 mg or even lower may curb the drug's toxicity without decreasing its effectiveness in patients with high plasma levels.
- Reviewing:
- van Luin M et al. J Acquir Immune Defic Syndr 2009 Oct 1; 52:240
SUMMARY AND COMMENT
Life Expectancy for HIV-Infected Patients in the U.S.
- November 2, 2009
- Sonia Nagy Chimienti, MD
Average life expectancy continues to improve, but disparities persist.
- Reviewing:
- Harrison KM et al. J Acquir Immune Defic Syndr 2009 Sep 2
SUMMARY AND COMMENT
No Increase in Transmitted HIV-Drug Resistance in Europe
- November 2, 2009
- Charles B. Hicks, MD
Between 2002 and 2006, the rates of transmitted drug resistance in Europe stabilized at <10%. Possible reasons abound.
- Reviewing:
- Vercauteren J et al. J Infect Dis 2009 Nov 15; 200:1503
SUMMARY AND COMMENT
A Glimmer of Hope for HIV VaccinesFree
- October 22, 2009
- Frances H. Priddy, MD, MPH, and Carlos del Rio, MD
A large trial has shown that a vaccine can protect against HIV acquisition. The task now is to figure out how to build on this initial success.
- Reviewing:
- Rerks-Ngarm S et al. N Engl J Med 2009 Oct 20
SUMMARY AND COMMENT
Resistance Development with Tenofovir/FTC vs. AZT/3TCFree
- October 19, 2009
- Jonathan Z. Li, MD, and Paul E. Sax, MD
In a comparative clinical trial, patients receiving tenofovir/FTC were less likely to develop resistance mutations during virologic failure than were those receiving AZT/3TC.
- Reviewing:
- Margot NA et al. J Acquir Immune Defic Syndr 2009 Oct 1; 52:209
SUMMARY AND COMMENT
A Better Way to Allocate ADAP Resources
- October 19, 2009
- Abigail Zuger, MD
When state funds cannot pay for everyone's antiretroviral therapy, treating high-risk patients first minimizes morbidity and mortality.
- Reviewing:
- Linas BP et al. J Acquir Immune Defic Syndr 2009 Aug 15; 51:513
SUMMARY AND COMMENT
IL-2 and HIV: Two Definitive Studies Published
- October 14, 2009
- Rajesh T. Gandhi, MD
- Infectious Diseases
Although interleukin-2 raises CD4-cell counts in HIV-infected patients, it does not improve clinical outcomes.
- Reviewing:
- The INSIGHT–ESPRIT Study Group and SILCAAT Scientific Committee. N Engl J Med 2009 Oct 15; 361:1548
SUMMARY AND COMMENT
HIV-Associated Pulmonary Arterial Hypertension Defies ARTFree
- October 9, 2009
- Abigail Zuger, MD
A large case series suggests that the prognosis of PAH is not dramatically altered by effective combination antiretroviral therapy.
- Reviewing:
- Degano B et al. AIDS 2009 Sep 16
SUMMARY AND COMMENT
Switching from Enfuvirtide to Raltegravir — Safe and Effective?
- October 9, 2009
- Charles B. Hicks, MD
New trial results support making such a switch while continuing both the NRTIs and the PIs in the original regimen.
- Reviewing:
- De Castro N et al. Clin Infect Dis 2009 Oct 15; 49:1259
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Immune Response from Bronchoalveolar Lavage Mononuclear Cells Diagnoses Active TB
- October 21, 2009
- By Neil M. Ampel, MD
- Infectious Diseases
ELISpot performed on bronchoalveolar mononuclear cells had a sensitivity of 91% and a specificity of 79% in diagnosing active disease.
- Reviewing:
- Am J Respir Crit Care Med 2009 Oct 1; 180:666
SUMMARY AND COMMENT
Surgical Masks or N95 Respirators for the Flu?Free
- October 21, 2009
- By Richard T. Ellison III, MD
- Infectious Diseases
In a randomized trial, surgical masks and N95 respirators provided healthcare workers with comparable protection against influenza.
- Reviewing:
- JAMA 2009 Oct 1
SUMMARY AND COMMENT
New Approach to Treating Tuberculosis
- October 13, 2009
- By Anthony L. Komaroff, MD
- General Medicine
Targeting nonreplicative bacteria might avert long courses of therapy for TB patients.
- Reviewing:
- Nature 2009 Oct 1; 461:621
SUMMARY AND COMMENT
2009 H1N1 Influenza in a Tour Group in China
- October 14, 2009
- By Mary E. Wilson, MD
- Infectious Diseases
Influenza developed in 30% of tour members who had talked with an H1N1-infected woman in the group but in none who had not.
- Reviewing:
- Emerg Infect Dis 2009 Oct; 15:1578
Jounal Watch HIV/AIDS Clinical Care summarizes important medical journal articles about a wide variety of HIV-related subjects including acute HIV infection, antiretroviral resistance, epidemiology, hepatitis, initial therapy, medication adherence, opportunistic infections, and STDs.
